“The true revolutionary is guided by great feelings of love.”Last night, the millions of the people of South Africa, majority of whom the working class and poor, and the billions of the rest of the people the world over, lost a true revolutionary, President Nelson Rolihlahla Mandela, Tata Madiba.The South African Communist Party joins the people of South Africa and the world in expressing its most sincere condolences to Ms. Graca Machel and the entire Mandela family on the loss of what President Zuma correctly described as South Africa’s greatest son, Comrade Mandela.We also wish to use this opportunity to express our solidarity with the African National Congress, an organisation that produced him and that he also served with distinction, as well as all his colleagues and comrades in our broader liberation movement. As Tata Madiba said, “It is not the kings and generals that make history but the masses of the people, the workers, the peasants. …”The passing away of Comrade Mandela marks an end to the life of one of the greatest revolutionaries of the 20th century, who fought for freedom and against all forms of oppression in both their countries and globally. As part of the masses that make history, Comrade Mandela’s contribution in the struggle for freedom was located and steeled in the collective membership and leadership of our revolutionary national liberation movement as led by the ANC — for he was not an island. In Comrade Mandela we had a brave and courageous soldier, patriot and internationalist who, to borrow from Che Guevara, was a true revolutionary guided by great feelings of love for his people, an outstanding feature of all genuine people’s revolutionaries.At his arrest in August 1962, Nelson Mandela was not only a member of the then underground South African Communist Party, but was also a member of our Party’s Central Committee. To us as South African communists, Comrade Mandela shall forever symbolise the monumental contribution of the SACP in our liberation struggle. The contribution of communists in the struggle to achieve the South African freedom has very few parallels in the history of our country. After his release from prison in 1990, Comrade Madiba became a great and close friend of the communists till his last days.The one major lesson we need to learn from Mandela and his generation of leaders was their commitment to principled unity within each of our Alliance formations as well as the unity of our Alliance as a whole and that of the entire mass democratic movement. Their generation struggled to build and cement the unity of our Alliance, and we therefore owe it to the memory of Comrade Madiba to preserve the unity of our Alliance. Let those who do not understand the extent to which blood was spilt in pursuance of Alliance unity be reminded not to throw mud at the legacy and memory of the likes of Madiba by being reckless and gambling with the unity of our Alliance.The SACP supported Madiba’s championing of national reconciliation. But national reconciliation for him never meant avoiding tackling the class and other social inequalities in our society, as some would like to make us believe today. For Madiba, national reconciliation was a platform to pursue the objective of building a more egalitarian South African society free of the scourge of racism, patriarchy and gross inequalities. And true national reconciliation shall never be achieved in a society still characterized by the yawning gap of inequalities and capitalist exploitation.In honour of this gallant fighter, the SACP will intensify the struggle against all forms of inequality, including intensifying the struggle for socialism, as the only political and economic solution to the problems facing humanity.For the SACP, the passing away of Madiba must give all those South Africans who had not fully embraced a democratic South Africa, and who still in one way or the other hanker to the era of white domination, a second chance to come to terms with a democratic South Africa founded on the principle of majority rule.We call upon all South Africans to emulate his example of selflessness, sacrifice, commitment and service to his people.The SACP says, “Hamba kahle Mkhonto!” [“Go well, brave warrior!”]FacebookTwitterWhatsAppEmailPrintMoreShare thisFacebookTwitterWhatsAppEmailPrintMoreShare this
IndiaAsia – Pacific In rural India, journalists face choice between covering pandemic and survival November 19, 2008 – Updated on January 20, 2016 Trainee journalist gunned down in Manipur, local media stage protests Organisation Reporters Without Borders is outraged by the fatal shooting on 17 November of Konsam Rishikanta, a young trainee journalist employed by the Imphal Free Press, a privately-owned English-language daily based in Imphal, the capital of the northeastern state of Manipur.”We support the strikes announced by the local press in protest against this cowardly murder as they could help to prevent it being left unpunished,” Reporters Without Borders said. “Both the Manipur state government and the federal authorities must ensure that the murder investigation has the resources it needs to establish the motive and identify those responsible.”Police found Rishikanta’s body in a deserted alley in the middle of the afternoon of 17 November. He had been shot three times. Neighbours reportedly said they heard a total of 10 gunshots. The motive for the murder is not yet known and no group has claimed responsibility.Imphal Free Press journalist Pradip Phanjoubam said Rishikanta had been expected at the newspaper for the night shift. He added that he did not think the shooting was linked to any report published in the newspaper. Rishikanta’s family said he had gone that morning to the company where he used to work to request pay that was still due to him, and never returned.The Imphal Free Press received several puzzling calls that day asking if Rishikanta had arrived at the newspaper. A short while after receiving the calls, the Imphal Free Press learned from other newspapers that his body had been discovered.All the Imphal-based daily newspapers decided at an emergency meeting at the Manipur Press Club to stage a four-day strike in protest against the murder. The All Manipur Working Journalists Union (AMWJU) announced that it would suspend all publications and TV broadcasts for an unspecified period beginning tomorrow.The members of this union also called on Chief Minister Okram Ibobi Singh to ensure that the murder was investigated promptly. Singh promised that every possible would be done to arrest Rishikanta’s killers.Journalists are often threatened in Manipur by both the security forces and armed separatists. There have been several cases of journalists being shot by unidentified gunmen in recent years in Manipur. Follow the news on India June 10, 2021 Find out more News News Receive email alerts India: RSF denounces “systemic repression” of Manipur’s media News Help by sharing this information News IndiaAsia – Pacific to go further April 27, 2021 Find out more RSF_en RSF demands release of detained Indian journalist Siddique Kappan, hospitalised with Covid-19 March 3, 2021 Find out more
Afghanistan : “No just and lasting peace in Afghanistan without guarantees for press freedom” Addressing a news conference today in Kabul, Reporters Without Borders secretary-general Jean-François Julliard urged President Hamid Karzai and the rest of the Afghan government to make it one of their priorities to defend press freedom. Accompanied by representatives of Afghan journalists’ organisations, Julliard gave the press conference on the penultimate day of a one-week fact-finding visit to Afghanistan at the head of a Reporters Without Borders delegation.“The press freedom situation is getting worse in Afghanistan and it is the government’s duty to reverse this disturbing trend,” Julliard said. “The country cannot continue to develop and progress towards democracy without a free and independent press. The president and his government must get fully involved in this issue and must take measures that give journalists more freedom to work. Much needs to be done in Afghanistan but the country will not be able to recover from 30 years of war without free and diverse news media.”Reporters Without Borders continued: “The threats against Afghan journalists and visiting foreign journalists are becoming more and more diverse. As well as the Taliban, who have never ceased to threaten to kill journalists who do not comply with their demands, there are now criminals and mafia groups.“Afghan journalists are free to express their views – as long as they stay clear of the country’s only truly taboo subject, Islam – but they operate in very difficult security conditions. The south and the east of the country are extremely unstable and fewer and fewer journalists are visiting these regions, which are no longer under government control and have become black holes for news and information.”The Reporters Without Borders delegation visited the Kabul provisional detention centre on 12 January to meet with journalist Perwiz Kambakhsh, who is serving a 20-year prison sentence for downloading an essay about women’s rights in Islam. He was originally sentenced to death.“As long as a citizen can be sentenced to death or to a long jail term just for reading a report on the Internet, we will not be able to say there is free expression in Afghanistan. Perwiz Kambakhsh must be released as soon as possible. He committed no crime and this case, which has been marred by judicial irregularities, is a grave stain on Afghanistan’s image. We told all the officials we met that his conviction must be overturned.”Two journalists were killed in 2008 and around 50 were attacked or injured. Reporters Without Borders believes President Karzai must get to grips with this issue and make it very clear that he will not let impunity take hold as regards violence against journalists. Many live in fear, and it is the job of the authorities to take measures to reassure them and to enable them to work without constant security concerns. It is deplorable than around 10 women journalists have been forced to abandon their work in recent months because of threats. Few of them got the necessary protection.The authorities need to be more effective in solving the cases of journalists who have been murdered or who have been the victims of threats. Proper investigations need to be carried out to identify those responsible. It is unacceptable that the murders of Zakia Zaki and Abdul Samad Rohani have gone unpunished.Reporters Without Borders also called for the rapid adoption of a proposed media law. Many journalists’ representatives are expecting a lot from this bill, which is still being examined and which has been a victim of the difficulties that the parliament and government are having in working together.The government must also envisage drafting a law facilitating access to information. All the journalists who met the delegation said it was hard to get reliable information or comments from officials. Reporters Without Borders said: “In any important event linked to the ongoing conflict, there are at least five different versions of the facts – the Taliban version, the defence ministry version, the version of the president’s office, the version of the International Security Assistance Force, and the version of the few eye-witnesses who are ready to talk to the press. The government version is often the longest and hardest to obtain. While we welcome the creation of a Media Centre, the government must communicate better and make itself more available to journalists.”Reporters Without Borders also believes certain media owners must stop meddling in editorial content. The owners of media and their reporters should be kept far apart. Too many media are used for partisan purposes by their shareholders, and news quality suffers as a result. Journalists’ organisations are also discussing a code of conduct for the media and Reporters Without Borders supports this initiative. Reporters Without Borders also hails the efforts of Afghan journalists’ organisations to unite in defence of press freedom.As well as Julliard, the Reporters Without Borders delegation consisted of Vincent Brossel, the head of its Asia Desk, and Réza Moini, the staff member responsible for Afghanistan. They met the justice minister, the culture and information minister, a Council of Ulemas representative, civil society representatives, ISAF officials, diplomats and many journalists and media organisations.The delegation arrived in Afghanistan on 10 January and is due to leave tomorrow. Reporters Without Borders will issue a detailed report on the visit in the coming weeks. Situation getting more critical for Afghan women journalists, report says News January 15, 2009 – Updated on January 20, 2016 Reporters Without Borders gives Kabul news conference, urges government to make press freedom a priority Help by sharing this information to go further Receive email alerts News Organisation May 3, 2021 Find out more Addressing a news conference today in Kabul, Reporters Without Borders secretary-general Jean-François Julliard urged President Hamid Karzai and the rest of the Afghan government to make it one of their priorities to defend press freedom. Accompanied by representatives of Afghan journalists’ organisations, Julliard gave the press conference on the penultimate day of a one-week fact-finding visit to Afghanistan at the head of a Reporters Without Borders delegation. News RSF asks International Criminal Court to investigate murders of journalists in Afghanistan June 2, 2021 Find out more AfghanistanAsia – Pacific RSF_en News AfghanistanAsia – Pacific Follow the news on Afghanistan March 11, 2021 Find out more
Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy Community News EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Make a comment Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday Herbeauty10 Special Massage Techniques That Will Make You Return For MoreHerbeautyHerbeautyHerbeauty18 Ways To Get Rid Of HiccupsHerbeautyHerbeautyHerbeautyThe Most Heartwarming Moments Between Father And DaughterHerbeautyHerbeautyHerbeautyTop Important Things You Never Knew About MicrobladingHerbeautyHerbeautyHerbeauty9 Hollywood Divas Who Fell In Love With WomenHerbeautyHerbeautyHerbeauty12 Most Breathtaking Trends In Fashion HistoryHerbeautyHerbeauty Top of the News faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,PCC – EducationVirtual Schools PasadenaDarrell Done EducationHomes Solve Community/Gov/Pub SafetyPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes More Cool Stuff 8 recommended0 commentsShareShareTweetSharePin it What would you create with a 3D printer? That is precisely the question Marshall Fundamental School teacher Miguel Almena asked his students and colleagues when the school received a 3D printer donated by the Pasadena Educational Foundation. The answer: trumpet mouthpieces.Trumpet mouthpieces break often, are expensive for the school to replace, and take a long time to arrive. Together with music teacher Joel Lopez, Almena and his students have manufactured 5 new trumpet mouthpieces using their new 3D printer technology. The mouthpieces will be utilized in this year’s Holiday Concert, December 13 at 6:00 p.m. at Pasadena High School (2925 E Sierra Madre Blvd., Pasadena).Marshall is one of nine Pasadena Unified School District schools that received the donated printers. “Through the support of a generous donor, we can give the students of PUSD the opportunity to get their hands on next-gen technology and learn the creativity and collaboration skills needed for the jobs of tomorrow.” says Patrick Conyers, Executive Director of the Pasadena Educational Foundation.“Creating the trumpet mouthpieces was a perfect opportunity to provide a real-world l earning opportunity for our students,” said Almena. “We found a need and utilized our 21st century technology to fill it.”Marshall and several other PUSD schools now offer courses utilizing the 3D printers. Students are introduced to design and manufacturing through team-based activities that replicate the manufacturing process from concept to design to fabrication to marketing.More information on the Pasadena Educational Foundation 3D printer program in PUSD is available online at: http://pasedfoundation.org/pusd3d Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadena Name (required) Mail (required) (not be published) Website Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. Your email address will not be published. Required fields are marked * Business News Subscribe First Heatwave Expected Next Week Community News Business: Marketing Column Marshall’s Holiday Concert Features Trumpets with 3D Printed Mouthpieces From STAFF REPORTS Published on Thursday, December 12, 2013 | 5:46 pm
News UpdatesBombay HC Appoints Sr Adv Nitin Thakker As Legal Guardian And Manager Of All Properties & Assets Of 87-year-old Lawyer Who Is Now Incapacitated [Read Petition] Nitish Kashyap15 Aug 2020 4:04 AMShare This – xThe Bombay High Court while hearing an ‘unusual suit’ filed by Senior Advocate Nitin Thakker and another advocate who worked for 87-year-old Solicitor and Advocate Kirit Damania previously for several years, Court invoked inherent power under Section 151 of CPC and declared Nitin Thakker as the lawful guardian and manager of all assets and affairs of the octogenarian who is incapacitated…Your free access to Live Law has expiredTo read the article, get a premium account.Your Subscription Supports Independent JournalismSubscription starts from ₹ 599+GST (For 6 Months)View PlansPremium account gives you:Unlimited access to Live Law Archives, Weekly/Monthly Digest, Exclusive Notifications, Comments.Reading experience of Ad Free Version, Petition Copies, Judgement/Order Copies.Subscribe NowAlready a subscriber?LoginThe Bombay High Court while hearing an ‘unusual suit’ filed by Senior Advocate Nitin Thakker and another advocate who worked for 87-year-old Solicitor and Advocate Kirit Damania previously for several years, Court invoked inherent power under Section 151 of CPC and declared Nitin Thakker as the lawful guardian and manager of all assets and affairs of the octogenarian who is incapacitated at present after he was hospitalised on July 25 and is presently in critical condition. Justice GS Patel observed- “Mr Damania is neither mentally challenged nor of unsound mind nor a minor. He has no family. He is incapacitated by an illness and the current laws of guardianship do no provide any recourse in a situation like this. This is therefore something of a vacuum in law that however does not mean that Courts are helpless or that situations such as these should go unattended or unaddressed.” Kirit Damania started his practise as a lawyer with the firm M/s Bhaisankar Kanga & Girdharilal and later he started his own firm called M/s Kirit N Damania & Co. and is the sole proprietor. In 2006, Mr.Damania started a charitable trust called Shri Rang Avdhoot foundation along with two others as trustees. Mr.Damania suffers from several health problems including heart and kidney. He also has diabetes and blood pressure. He has a caretaker, a servant and one personal chauffeur. Apart from this, he has no family. He lives alone in an apartment at Mahalaxmi. He was admitted to the ICU at HN Reliance Foundation Hospital on July 25, 2020. After being in the ICU for a few days, Mr.Damania was shifted to a room and is now completely bed-ridden and incapable of making any cogent decisions for himself. Even though he was conscious, he could not recognize anyone. Also, Mr.Damania never issued any Power of Attorney and a few days back, he had an attack of meningitis and his condition is now said to be critical. Senior Advocate Sharan Jagtiani appeared on behalf of the two plaintiffs and submitted that Mr.Damania’s present hospital bills are significant, over one lakh per day and are being partly paid through his credit cards and partly by his friends and well wishers. Moreover, it is not possible for Mr.Damania to operate his bank accounts or to attend to his daily affairs. Thus, Jagtiani urged that the application for his client to be appointed legal guardian be allowed. Justice Patel observed- “The present case falls only partly within the provisions of Order 32-A (2)(c). But as this plaint points out, the state of law in India simply does not make any sort of provision for a situation such as the present one. Mr Damania is neither mentally challenged nor of unsound mind nor a minor. He has no family. He is incapacitated by an illness and the current laws of guardianship do no provide any recourse in a situation like this. This is therefore something of a vacuum in law that however does not mean that Courts are helpless or that situations such as these should go unattended or unaddressed.” Drawing support from Order 32 A of CPC, previous order passed by Justice SJ Kathawalla and Section 151 of CPC, Justice Patel decreed the suit and declared Senior Advocate Nitin Thakker as the lawful guardian.Click Here To Download Application[Read Application]Subscribe to LiveLaw, enjoy Ad free version and other unlimited features, just INR 599 Click here to Subscribe. All payment options available.loading….Next Story
One of the linchpins of the UK’s contribution to the burgeoning field of astrobiology is the Beagle 2 mission, due to fly to Mars in 2003 on the Mars Express bus. Given that NASA has declared its intention to focus on “whole planet” geological investigation in its future Mars missions, beginning with the Mars Exploration Rovers which are due to fly in 2003/2004, the UK is well placed to consider post-Beagle 2 astrobiology-focused Mars missions to ensure its leadership in the future in astrobiology. In this paper we present such a proposal – Vanguard.
View post tag: Incat Crowther February 18, 2016 Authorities View post tag: Philippine Navy The Philippine Government has contracted the Australian vessel designer Incat Crowther to design a 50m multi-mission monohull patrol vessel.Two identical vessels of this type will be built in Manilla by Josefa Slipways. The primary role of the vessels is to combat illegal fishing for the Philippine government.With the local fishing industry losing billions of dollars to illegal fishing, these assets are expected to enhance law enforcement’s capability to patrol and protect territorial waters.The multi-mission nature of the vessels allows them to be used for disaster relief and/or rescue operations, as well as to serve as a platform for research.The Department of Agriculture (DA) with their operating agency, Bureau of Fisheries and Aquatic Resources (BFAR) will operate the vessels.The 50-meter vessel will be powered by two (2) Mitsubishi S16R2-T2MPTK engines, coupled with a Masson MMW18000 gearboxes and fixed pitch propellers. Two (2) Yanmar 6HAL2-WHT generators will service the vessel’s electrical needs with an additional emergency generator.One embarked 9-meter riggid hull inflatable boat (RHIB) will be deployed from a specially designed well with a transom door. Back to overview,Home naval-today Philippine Government to build two new patrol vessels Share this article Philippine Government to build two new patrol vessels
Communities Secretary Rt Hon James Brokenshire MP welcomed the Budget and said it will boost efforts to build the homes communities need, restore the dream of home ownership, help our high streets and support councils to deliver local services.Building on the current comprehensive package of reform and targeted investment to deliver the homes the country needs, the measures outlined in the Budget include: Contact form https://forms.communit… This Budget provides positive news for those struggling to get on the housing ladder with certainty given on the future of Help to Buy and freeing up councils to deliver a new generation of council housing. It also supports communities across the country by helping councils deliver services for their most vulnerable residents while also helping our high streets to flourish. General enquiries: please use this number if you are a member of the public 030 3444 0000 Email [email protected] Recognising the pressures faced by councils, almost £1 billion of extra funding will be provided to help deliver the services communities need and support the most vulnerable residents: 2 Marsham StreetLondonSW1P 4DF Please use this number if you are a journalist wishing to speak to Press Office 0303 444 1209 a £650 million boost for adults and children’s social care, including £240 million to support vulnerable people over winter months and help manage the impact on the NHS business rates relief targeted at small retailers to cut their bills by a third and a new mandatory relief for public lavatories, building on over £10 billion of business rates support since 2016 Building the homes communities needThe Chancellor has confirmed that the biggest barrier to councils building homes, the Housing Revenue Account borrowing cap, has been removed entirely – freeing up councils to deliver a new generation of council housing – up to an estimated 10,000 homes a year.In a move to help more first-time buyers get a foot on the housing ladder, a new Help to Buy scheme has been announced from April 2021 – restricted to first-time buyers and including regional property price caps to ensure it is more targeted on people who need it most.And with most first-time buyers now exempt from paying Stamp Duty following last year’s Budget – benefitting over 120,000 buyers so far – this year’s Budget went a step further by extending this relief to all first-time buyers of shared ownership properties worth up to £500,000 – and making this retrospective, so any first-time buyer who has made such a purchase since the last Budget will benefit.To make sure that the infrastructure is in place to support new and existing communities ahead of development of new homes, the Housing Infrastructure Fund has been boosted by £500 million – bringing the total to £5.5 billion with the potential to unlock up to 650,000 homes.Grant funding of £291 million for vital infrastructure on the Docklands Light Railway in East London has been announced, meaning less pressure on existing services in the area and the potential to unlock over 18,000 homes.The next wave of deals with 9 housing associations were announced, allocating £653 million from the Affordable Homes Programme to deliver over 13,000 additional affordable housing starts by March 2022 and £1 billion of new guarantees to support small and medium sized builders, implemented by the British Business Bank.A consultation on a package of planning reform to allow greater flexibility to extend existing buildings upwards and allow a change of use has been launched – to ensure that the planning system is speeding up the delivery of homes and supporting the regeneration of high streets.Support was confirmed for up to 500 neighbourhoods to develop plans to allocate or permission land for homes sold at a discount.The government has also committed to working with local partners in the Oxford-Cambridge Arc to maximise sustainable economic growth in a response to the National Infrastructure Commission’s report.Almost £1 billion extra support for local servicesThis Budget has provided a boost of £650 million to help councils support the most vulnerable people in their communities. Of this £240 million will be focused on winter pressures next year with flexibility to use the remainder where it is needed most – for adult or children’s services.This is on top of the £240 million announced last month to address winter social care pressures this year.An additional £84 million over 5 years will also be made available as a targeted children’s social care fund over the next 5 years, along with an additional £55 million Disabled Facilities Grant in this financial year.This will mean councils will be able to deliver the services their residents need while also protecting them from excessive Council Tax bills.The Budget will also provide a further £420 million to councils to fix potholes and carry out other repairs to improve roads, allow better access to workplaces, high streets and other community facilities.Help for the high streetA £1.5 billion plan that includes a cut to the business rates bills for small retailers worth almost £900 million over 2 years, funding to transform town centres and a relaxation of planning rules has been announced as part of the Budget to support the country’s high streets.This includes: Office address and general enquiries This is alongside a package to support high-streets meet the new challenges brought about by changing shopping habits, providing short-term relief for struggling retailers and a long-term vision for town centres.Communities Secretary Rt Hon James Brokenshire MP said: continuing to help people onto the housing ladder by announcing a new Help to Buy scheme from April 2021 and exploring proposals to deliver a new wave of shared ownership homes supporting councils and housing associations by removing borrowing restrictions to enable them to deliver a new generation of council housing and affordable homes further planning reforms to make the most of available space for homes and ensuring developers pay their fair share to support new and existing communities If your enquiry is related to COVID-19 please check our guidance page first before you contact us – https://www.gov.uk/guidance/coronavirus-covid-19-guidance-for-local-government.If you still need to contact us please use the contact form above to get in touch, because of coronavirus (COVID-19). If you send it by post it will not receive a reply within normal timescale. relaxing planning rules to support new mixed-use businesses on the high street and the conversion of under-used retail units into offices and homes This is accompanied by additional support for local leadership to prepare and implement new strategies for their high street, including a new High Streets Taskforce to offer support and advice to help revitalise high streets.This Budget also went further to fire-up the Northern Powerhouse, fuel the Midlands Engine and back our regions across the UK by committing to refresh both strategies next year and increasing the Transforming Cities Fund to £2.4 billion to make it quicker and easier for people to get around in some of England’s biggest cities. Social media – MHCLG the launch of a £675 million Future High Streets Fund to transform local high streets so that they can remain firmly at the heart of communities; this will be used to improve infrastructure and transport and also support areas to redevelop under-used retail space into homes and offices, helping to restore high street properties and put historic buildings back into use Media enquiries Twitter – https://twitter.com/mhclgFlickr – http://www.flickr.com/photos/mhclgLinkedIn – http://www.linkedin.com/company/mhclg
Parker Treacy, M.B.A. ’12, NVC Alumni winner Cobli is big data for fleet and logistics in South America. Astraeus Technologies wins 2016 New Venture Competition Business Track <a href=”https://www.youtube.com/watch?v=K5vdm00l-6I” rel=”nofollow” target=”_blank”> <img src=”https://img.youtube.com/vi/K5vdm00l-6I/0.jpg” alt=”0″ title=”How To Choose The Correct Channel Type For Your Video Content ” /> </a> <a href=”https://www.youtube.com/watch?v=Cbf57d0oVeI” rel=”nofollow” target=”_blank”> <img src=”https://img.youtube.com/vi/Cbf57d0oVeI/0.jpg” alt=”0″ title=”How To Choose The Correct Channel Type For Your Video Content ” /> </a> This venture was clearly an investment in the future as Harvard Business School (HBS), the Harvard Ed Portal, and the Harvard i-lab presented 30 local high school students front-row seats to how entrepreneurship works.“So many people may have million-dollar ideas, but don’t know what to do with [them or] how to get started,” said Evander Pierre, a senior at Brighton High School (BHS) who hopes to start his own business. “It was amazing … to meet someone who has done something with their own idea, to have someone show you the way — that can change the future. I have a lot that I want to achieve, and this was an experience that will help put me on that path.”Wombi Rose, co-founder of Lovepop Cards, a company recognized from the TV shows “Shark Tank” and “The View,” met with students from BHS, Boston Public School’s Another Course to College and the West End House Boys and Girls Club.A highlight was the 2016 New Venture Competition (NVC) at HBS, where they saw students and alumni compete for more than $230,000 in startup funding.“This is our second year working with Harvard, and it’s a really high-level opportunity for our students,” said Daniel Cuddy, a teacher at BHS and senior career specialist with the Boston Private Industry Council, an organization that connects Boston citizens to education and employment opportunities.“They learn about the creative thinking and critical thinking that are so important to running a startup,” he said. “The experience also underscores academics, getting a strong background in coding, engineering, IT, and math. So they get a great idea of how companies start, how they work, and where they as individuals need to grow.”During the high school students’ participation in an entrepreneurial workshop, they brainstormed in groups, identifying problems and devising solutions. They envisioned an app that allowed customers to try on clothes digitally and a silent jackhammer that wouldn’t interrupt construction so students could work without noise disruption.“I loved being able to share my ideas in the workshop,” said Ivcel Ramos, a senior at Brighton High. “When I was little, I had lots of business ideas; there were just so many things I wanted to do. I’m very artistic and want to express my ideas through my work. This experience definitely motivated me to do much better in school, and to take advantage of every opportunity that I can. I really want to build my way to the top.”Julia Kemp, associate director of The Arthur Rock Center for Entrepreneurship, said the event was “all about discovery.”In the workshop, the students “came up with some high-caliber ideas,” she said. “These could be future applicants to Harvard or to HBS, so it felt very rewarding to work with them. We were blown away by how clever they were, and it was great to share that passion for entrepreneurship with them.”“We’re very thankful to Harvard as a partner,” Cuddy said. “It means a lot to inner-city youth to get access to Harvard Business School and connect with these coaches, leaders, and adults. It’s so important to our students, and it’s wonderful for them to interact with people who are really motivated and leading the way.”Winners from the New Venture Competition finale Cobli wins 2016 Alumni New Venture Competition NVC Business Track Winner Astraeus Technologies is a better screening test for lung cancer. UrSure, Inc. wins 2016 New Venture Competition Social Enterprise Track <a href=”https://www.youtube.com/watch?v=fxpTb1PYYqo” rel=”nofollow” target=”_blank”> <img src=”https://img.youtube.com/vi/fxpTb1PYYqo/0.jpg” alt=”0″ title=”How To Choose The Correct Channel Type For Your Video Content ” /> </a> NVC Social Enterprise winner UrSure, Inc. drives adherence to the HIV preventive drug, PrEP, with noninvasive, painless, cheap urine tests.
The researchers also investigated what maintained the nerve connections to the hair follicle stem cells. When they removed the muscle connected to the hair follicle, the sympathetic nerve retracted and the nerve connection to the hair follicle stem cells was lost, showing that the muscle was a necessary structural support to bridge the sympathetic nerve to the hair follicle.How the system developsIn addition to studying the hair follicle in its fully formed state, the researchers investigated how the system initially develops — how the muscle and nerve reach the hair follicle in the first place.“We discovered that the signal comes from the developing hair follicle itself. It secretes a protein that regulates the formation of the smooth muscle, which then attracts the sympathetic nerve. Then in the adult, the interaction turns around, with the nerve and muscle together regulating the hair follicle stem cells to regenerate the new hair follicle. It’s closing the whole circle — the developing hair follicle is establishing its own niche,” said Yulia Shwartz, a postdoctoral fellow in the Hsu lab. She was a co-first author of the study, along with Meryem Gonzalez-Celeiro, a graduate student in the Hsu Lab, and Chih-Lung Chen, a postdoctoral fellow in the Lin lab.Responding to the environmentWith these experiments, the researchers identified a two-component system that regulates hair follicle stem cells. The nerve is the signaling component that activates the stem cells through neurotransmitters, while the muscle is the structural component that allows the nerve fibers to directly connect with hair follicle stem cells.“You can regulate hair follicle stem cells in so many different ways, and they are wonderful models to study tissue regeneration,” Shwartz said. “This particular reaction is helpful for coupling tissue regeneration with changes in the outside world, such as temperature. It’s a two-layer response: goosebumps are a quick way to provide some sort of relief in the short term. But when the cold lasts, this becomes a nice mechanism for the stem cells to know it’s maybe time to regenerate new hair coat.”In the future, the researchers will further explore how the external environment might influence the stem cells in the skin, both under homeostasis and in repair situations such as wound healing.“We live in a constantly changing environment. Since the skin is always in contact with the outside world, it gives us a chance to study what mechanisms stem cells in our body use to integrate tissue production with changing demands, which is essential for organisms to thrive in this dynamic world,” Hsu said.This study was supported by the New York Stem Cell Foundation, Smith Family Foundation Odyssey Award, Pew Charitable Trusts, Harvard NeuroDiscovery Center, Harvard Stem Cell Institute, Harvard Medical School Dean’s Innovation Grant, American Cancer Society, National Institutes of Health, Taiwan Ministry of Science and Technology, and National Taiwan University Hospital. The Daily Gazette Sign up for daily emails to get the latest Harvard news. If you’ve ever wondered why we get goosebumps, you’re in good company — so did Charles Darwin, who mused about them in his writings on evolution. Goosebumps might protect animals with thick fur from the cold, but we humans don’t seem to benefit from the reaction much — so why has it been preserved during evolution all this time?In a new study, Harvard University scientists have discovered the reason: the cell types that cause goosebumps are also important for regulating the stem cells that regenerate the hair follicle and hair. Underneath the skin, the muscle that contracts to create goosebumps is necessary to bridge the sympathetic nerve’s connection to hair follicle stem cells. The sympathetic nerve reacts to cold by contracting the muscle and causing goosebumps in the short term, and by driving hair follicle stem cell activation and new hair growth over the long term.Published in the journal Cell, these findings in mice give researchers a better understanding of how different cell types interact to link stem cell activity with changes in the outside environment.“We have always been interested in understanding how stem cell behaviors are regulated by external stimuli,” said Ya-Chieh Hsu, the Alvin and Esta Star Associate Professor of Stem Cell and Regenerative Biology, who led the study in collaboration with Professor Sung-Jan Lin of National Taiwan University.“The skin is a fascinating system: it has multiple stem cells surrounded by diverse cell types, and is located at the interface between our body and the outside world. Therefore, its stem cells could potentially respond to a diverse array of stimuli — from the niche, the whole body, or even the outside environment,” explained Hsu. “In this study, we identify an interesting dual-component niche that not only regulates the stem cells under steady state, but also modulates stem cell behaviors according to temperature changes outside.”In response to the cold, the muscle (pink) in the hair follicle contracts, resulting in goosebumps. But in addition, the sympathetic nerve (green) releases neurotransmitters that target hair follicle stem cells (blue), causing them to activate and grow new hair. Credit: Shwartz, Gonzalez-Celeiro, Chen, et al./ CellA system for regulating hair growthMany organs are made of three types of tissue: epithelium, mesenchyme, and nerve. In the skin, these three lineages are organized in a special arrangement. The sympathetic nerve, part of our nervous system that controls body homeostasis and our responses to external stimuli, connects with a tiny smooth muscle in the mesenchyme. This smooth muscle in turn connects to hair follicle stem cells, a type of epithelial stem cell critical for regenerating the hair follicle as well as repairing wounds.The connection between the sympathetic nerve and the muscle has been well known, since they are the cellular basis behind goosebumps: the cold triggers sympathetic neurons to send a nerve signal, and the muscle reacts by contracting and causing the hair to stand on end. However, when examining the skin under extremely high resolution using electron microscopy, the researchers found that the sympathetic nerve not only associated with the muscle, but also formed a direct connection to the hair follicle stem cells. In fact, the nerve fibers wrapped around the hair follicle stem cells like a ribbon.“We could really see at an ultrastructure level how the nerve and the stem cell interact. Neurons tend to regulate excitable cells, like other neurons or muscle with synapses. But we were surprised to find that they form similar synapse-like structures with an epithelial stem cell, which is not a very typical target for neurons,” Hsu said.Next, the researchers confirmed that the nerve indeed targeted the stem cells. The sympathetic nervous system is normally activated at a constant low level to maintain body homeostasis, and the researchers found that this low level of nerve activity maintained the stem cells in a poised state ready for regeneration. Under prolonged cold, the nerve was activated at a much higher level and more neurotransmitters were released, causing the stem cells to activate quickly, regenerate the hair follicle, and grow new hair. The sympathetic nerve reacts to cold by contracting the muscle and causing goosebumps in the short term, and by driving hair follicle stem cell activation and new hair growth over the long term.